ErecAid Supplemental: Effective Erectile Dysfunction Treatment

Plethora Solutions Holdings PLC (“Plethora”, AIM: PLE), the specialist developer of products for the treatment and management of urological disorders, announces results of a study confirming the role its product, ErecAid, as a supplemental first line treatment for erectile dysfunction (ED). ErecAid is marketed through Plethora’s US subsidiary, Timm Medical Technologies, Inc. (“Timm Medical”, Minneapolis, MN).

The phosphodiesterase five inhibitors (PDE5i) such as Viagra and Cialis have become a major resource in the management of ED. Unfortunately, 30-50% of men report inadequate results with these oral medications. When patients fail to respond to the oral medications, physicians are often forced to consider more invasive and more complicated second line agents such as penile injections or urethral suppositories.

New data from a multi-center clinical trial led by investigators at Johns Hopkins School of Medicine demonstrate that use of the ErecAid vacuum erection device to augment PDE5i therapy can greatly improve patient satisfaction. Results of the study were presented at a recent North Central Sectional meeting of the American Urological Association.

Investigators at four separate study sites evaluated 69 men aged 36 to 82 with ED of diverse etiology who had responded inadequately to PDE5i therapy. Study subjects were allowed to continue use of PDE5i’s but were instructed to use the ErecAid device as an adjunct to their current oral medication. Study subjects were assessed using three validated measurements of erectile function and sexual satisfaction: the International Index of Erectile Function (IIEF-5), the Sexual Encounter Profile (SEP-2 and SEP-3) and the Global Patient Assessment Scale (GAPS).

After 4 weeks of supplemental treatment with ErecAid, the IIEF-5 score improved substantially from a baseline of 9.0 to 17.6 (p<0.001). Moreover, of the 34 subjects unable to achieve an erection satisfactory for intercourse at baseline (SEP-2 response of “no”), 27 subjects (79%) reported erections satisfactory for intercourse following the addition of ErecAid (p<0.001). Finally, of 42 subjects reporting no or slight response to PDE5i at baseline (GAPS responses of “not at all” or “slightly”), 31 (74%) reported moderate or great improvement (GAPS responses of “moderately” or “greatly”) at the end of the 4 week study (p<0.001).

According to Dr. Arthur Burnett, Professor of Urology at Johns Hopkins School of Medicine and the lead investigator of this trial, “This study confirms an earlier trial that many patients can achieve excellent results using ErecAid as an addition to oral PDE5i therapy. Based upon these results, I would encourage physicians treating ED to consider the importance of this approach in their treatment protocols and to discuss this option with their patients.”

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Hope For Erectile Dysfunction Through Research

Impotence and Erectile Dysfunction Research

Advances in suppositories, injectable medications, implants, and vacuum devices have expanded the options for men seeking treatment for ED. These advances have also helped increase the number of men seeking treatment. Gene therapy for ED is now being tested in several centers and may offer a long-lasting therapeutic approach for ED.

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sponsors programs aimed at understanding the causes of erectile dysfunction and finding treatments to reverse its effects. NIDDK’s Division of Kidney, Urologic, and Hematologic Diseases supported the researchers who developed Viagra and continue to support basic research into the mechanisms of erection and the diseases that impair normal function at the cellular and molecular levels, including diabetes and high blood pressure.

Points to Remember

  • Erectile dysfunction (ED) is the repeated inability to get or keep an erection firm enough for sexual intercourse.
  • Erectile dysfunction� � affects 15 to 30 million American men.
  • Erectile dysfunction� � usually has a physical cause.
  • Erectile dysfunction� � is treatable at all ages.
  • Treatments include psychotherapy, drug therapy, vacuum devices, and surgery.